A conceptual framework to assess the impact of training on equipment cost and availability in the military context

Designing military support is challenging and current practices need to be reviewed and improved. This paper gives an overview of the Industry current practices in designing military support under Ministry of Defence/Industry agreements (in particular for Contracting for Availability (CfA)), and identifies challenges and opportunities for improvement. E.g. training delivery was identified as an important opportunity for improving the CfA in-service phase. Thus, an innovative conceptual framework is presented to assess the impact of training on the equipment availability and cost. Additionally, guidelines for improving the current training delivery strategies are presented, which can also be applied to other Industry contexts

The perils of tardy PPSR registration: Pozzebon (Trustee) v Australian Gaming and Entertainment Ltd

Copyright © 2014 LexisNexis. This article is made available per the publisher's Content Sharing policy.The recent decision of Pozzebon (Trustee) v Australian Gaming and Entertainment Ltd1 serves as a cautionary tale to secured lenders. It illustrates how a failure to register a security interest on the Personal Property Securities Register (PPSR) within 20 business days of execution may have dire consequences, rendering the security worthless if the corporate security provider enters external administration

Threshold phenomena in erosion driven by subsurface flow

We study channelization and slope destabilization driven by subsurface (groundwater) flow in a laboratory experiment. The pressure of the water entering the sandpile from below as well as the slope of the sandpile are varied. We present quantitative understanding of the three modes of sediment mobilization in this experiment: surface erosion, fluidization, and slumping. The onset of erosion is controlled not only by shear stresses caused by surfical flows, but also hydrodynamic stresses deriving from subsurface flows. These additional forces require modification of the critical Shields criterion. Whereas surface flows alone can mobilize surface grains only when the water flux exceeds a threshold, subsurface flows cause this threshold to vanish at slopes steeper than a critical angle substantially smaller than the maximum angle of stability. Slopes above this critical angle are unstable to channelization by any amount of fluid reaching the surface.Comment: 9 pages, 11 figure

Unconventional PDV applications: detecting plasma and radiation

Author Institution: Sandia National LaboratoriesSlides presented at the 2018 Photonic Doppler Velocimetry (PDV) Users Workshop, Drury Plaza Hotel, Santa Fe, New Mexico, May 16-18, 2018

Simulating the influences of groundwater on regional geomorphology using a distributed, dynamic, landscape evolution modelling platform

A dynamic landscape evolution modelling platform (CLiDE) is presented that allows a variety of Earth system interactions to be explored under differing environmental forcing factors. Representation of distributed surface and subsurface hydrology within CLiDE is suited to simulation at sub-annual to centennial time-scales. In this study the hydrological components of CLiDE are evaluated against analytical solutions and recorded datasets. The impact of differing groundwater regimes on sediment discharge is examined for a simple, idealised catchment, Sediment discharge is found to be a function of the evolving catchment morphology. Application of CLiDE to the upper Eden Valley catchment, UK, suggests the addition of baseflow-return from groundwater into the fluvial system modifies the total catchment sediment discharge and the spatio-temporal distribution of sediment fluxes during storm events. The occurrence of a storm following a period of appreciable antecedent rainfall is found to increase simulated sediment fluxes

The Essential Toxin: Impact of Zinc on Human Health

Compared to several other metal ions with similar chemical properties, zinc is relatively harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a rare event. In addition to acute intoxication, long-term, high-dose zinc supplementation interferes with the uptake of copper. Hence, many of its toxic effects are in fact due to copper deficiency. While systemic homeostasis and efficient regulatory mechanisms on the cellular level generally prevent the uptake of cytotoxic doses of exogenous zinc, endogenous zinc plays a significant role in cytotoxic events in single cells. Here, zinc influences apoptosis by acting on several molecular regulators of programmed cell death, including caspases and proteins from the Bcl and Bax families. One organ where zinc is prominently involved in cell death is the brain, and cytotoxicity in consequence of ischemia or trauma involves the accumulation of free zinc. Rather than being a toxic metal ion, zinc is an essential trace element. Whereas intoxication by excessive exposure is rare, zinc deficiency is widespread and has a detrimental impact on growth, neuronal development, and immunity, and in severe cases its consequences are lethal. Zinc deficiency caused by malnutrition and foods with low bioavailability, aging, certain diseases, or deregulated homeostasis is a far more common risk to human health than intoxication

Functional analysis of a novel ENU-induced PHD finger 11 (Phf11) mouse mutant

Previously, human genetic studies have shown association between polymorphisms within the gene encoding plant homeodomain zinc finger protein 11 (PHF11) and asthma-related phenotypes. Initial functional studies have suggested that PHF11 may be involved in the immune response through regulation of T cell activities. In order to study further the gene’s functions, we have investigated the mouse Phf11 locus. We have established and characterised a mouse line harbouring a point mutation in the PHD domain of Phf11. Full-length mouse cDNA for Phf11 was obtained by applying rapid amplification of cDNA ends (RACE). All five exons encoding the PHD domain of Phf11 were directly sequenced in 3840 mouse DNA samples from the UK MRC Harwell ENU (N-ethyl-N-nitrosourea)-mutagenised DNA archive. Mice harbouring a valine to alanine substitution, predicted to have a significant functional impact on the PHD zinc finger domain, were re-derived. These Phf11 mutant mice were outcrossed to C3H mice and then backcrossed for ten generations in order to establish a congenic line harbouring the single point mutation in Phf11. Macroscopic examination, haematology and histological examination of lung structure revealed no significant differences between mutant and wild-type mice. After administration of lipopolysaccharide, the level of expression of Il2, NF-kB and Setdb2 were significantly increased in Phf11 mutant homozygous lungs compared to control littermates. Our results provide evidence that Phf11 can operate as a Th1 cell regulator in immune responses. Moreover, our data indicate that these mice may provide a useful model for future studies on Phf11. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00335-014-9535-x) contains supplementary material, which is available to authorised users

Review of the modelling approaches for availability contracts in the military context

The defence context more recently has been experiencing a significant shift towards servitization. As competition has increased, commercial strategies are increasingly moving towards providing through-life solutions for complex engineering products such as submarines. Within such a context value for money is an essential driver in a life cycle sense for selecting a bid. The defence sector has largely been affected by this change in the business environment. Industrial Product Service System (IPS2) is a model of providing services that satisfy industrial customers and aims to reduce lifecycle impacts of products and services through product servicing, remanufacturing and recycling. This approach has proved to be an effective solution to enhance the services support in military projects. IPS2 offers client value by responding more efficiently to the client demands with reduced prices; it is delivered in the form of contracting approaches between Ministry of Defence (MoD) and industry; these contracts can differ in several aspects as risk sharing, application level, ownership policy and supportability specifications vary. This research focuses on Contracting for Availability (CfA), which is a particular approach of IPS2.The paper aims to present the review of literature in designing support strategies for CfA, identifying the good practices and challenges, and to propose a systematic approach to fill the industrial and academic gap towards an optimization of the current modelling process. This work starts by presenting a literature review in IPS2; it then moves into the optimization processes, describing how contractors currently design a long term service support contract in the military context with better value for money and high level of system readiness. The key cost and performance drivers are identified and a framework is presented to enhance the design process of CfA. The methodology of the paper relies on literature. This research aims to extend the work of several authors in predicting the cost of services in the military contracts